Long-Term Effect of a Luteinizing-Hormone-Releasing Hormone Analogue (Buserelin) on Cryptorchid Testes (Extended Summary)
نویسندگان
چکیده
منابع مشابه
Human malignant melanomas express receptors for luteinizing hormone releasing hormone allowing targeted therapy with cytotoxic luteinizing hormone releasing hormone analogue.
Cytotoxic analogue of luteinizing hormone releasing hormone (LHRH), AN-207, binds with high affinity to LHRH receptors and can be targeted to tumors expressing these receptors. We investigated the expression of LHRH receptors in surgical specimens of human malignant melanoma and evaluated the effects of AN-207 in models of human melanoma. Human melanoma specimens derived from primary tumors or ...
متن کاملTREATMENT OF PRECOCIOUS PUBERTY BY A LONG-ACTING GONADOTROPIN-RELEASING HORMONE ANALOGUE IN CHILDREN
The GnRH analogue has been shown to be effective in the treatment of precocious puberty when given as a daily subcutaneous injection. We studied the effectiveness of a long-acting GnRH analogue, Triptoreline, for the treatment of central precocity, by suppressing gonadotropin and estradiol secretion in three children with true precocious puberty. One month after single dose intramuscular i...
متن کاملLuteinizing hormone-releasing hormone antagonists.
BACKGROUND Luteinizing hormone-releasing hormone (LH-RH) plays a central role in the vertebrate reproduction by regulating gonadal activity. Based on its binding to pituitary LH-RH receptors, as well as to LH-RH receptors expressed on cancer cells, LH-RH agonists and antagonists have been developed for different therapeutic applications. OBJECTIVE/METHOD Here we give an overview of the most r...
متن کاملThe effect of short-term treatments of a gonadotropinreleasing hormone analog (buserelin) on sciatic nerve regeneration
Gonadotropin-releasing hormone (GnRH) has neuromodulatory roles in central and peripheral nervous systems. The purpose of this study is to evaluate the effect of GnRH analog (buserelin) on peripheral nerve regeneration. Forty adult male rats were divided into buserelin-treated, normal saline, sham surgery, and castrated + buserelin groups. The left sciatic nerve was crushed by a fine forceps an...
متن کاملHormone Secretion by Experimental Cryptorchid Testes *
This investigation has been aided by a grant from the Dr. Wallace C. and Clara A. Abbott Memorial Fund of The University of Chicago. Grateful acknowledgment is made to the following individuals for providing the gonadotrophic substances employed in the investigation. To Mr. Donald C. Wonder for Gonadin; to Dr. Oliver Kamm for Antuitrin-S; to Dr. J. A. Morrell for Prospermine; and to Dr. G. H. H...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hormone Research
سال: 1988
ISSN: 1423-0046,0301-0163
DOI: 10.1159/000181062